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Pathways Recommended: PROTAC
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PROTAC BRAF-V600E degrader-2

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-137488
    PROTAC BRAF-V600E degrader-2

    		PROTACs Raf Cancer
    PROTAC BRAF-V600E degrader-2 (compound 12) is a potent BRAF-V600E degrader with Kds of 14.4 nM and 9.5 nM for BRAF and BRAF-V600E, respectively. PROTAC BRAF-V600E degrader-2 selectively degraded the kinase domain of BRAF-V600E but not the wild-type BRAF. PROTAC BRAF-V600E degrader-2 inhibits melanoma cell growth .
    <em>PROTAC</em> <em>BRAF-V600E</em> <em>degrader-2</em>

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